Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay
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چکیده
منابع مشابه
Dissociated human dermal papilla cells induce hair follicle neogenesis in grafted dermal-epidermal composites
Cells. Human dermal papilla cells isolated from temporal scalp dermis (Promocell, Heidelberg, Germany) from five female donors (HDP41, HDP43, HDP44, HDP47, and HDP52) and one male donor (HDP60), named according to donor age in years, were propagated in vitro according to manufacturer’s recommendations. Keratinocytes were isolated from neonatal foreskins and were cultured in serum-free medium (K...
متن کاملCultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis.
Adult rat pelage follicle dermal papilla cells induced follicle neogenesis and external hair growth when associated with adult footpad skin epidermis. They thus demonstrated a capacity to completely change the structural arrangement and gene expression of adult epidermis--an ability previously undocumented for cultured adult cells. Isolation chambers ensured that de novo follicle formation must...
متن کاملMethods for the isolation and 3D culture of dermal papilla cells from human hair follicles
The dermal papilla is a cluster of mesenchymal cells located at the base of the hair follicle which have a number of important roles in the regulation of hair growth. As a consequence, in vitro models of these cells are widely used to study the molecular mechanisms which underlie hair follicle induction, growth and maintenance. While dermal papilla from rodent hair follicles can be digested pri...
متن کاملPoor Capability of 3D-Cultured Adipose-Derived Stem Cells to Induce Hair Follicles in Contrast to 3D-Cultured Dermal Papilla Cells
662 Ann Dermatol Received April 3, 2015, Revised August 18, 2015, Accepted for publication September 24, 2015 Corresponding author: Young Kwan Sung, Department of Immunology, Kyungpook National University School of Medicine, 680 Gukchaebosangro, Jung-gu, Daegu 41944, Korea. Tel: 82-53-420-4874, Fax: 82-53-423-4628, E-mail: [email protected] This is an Open Access article distributed under the ter...
متن کاملhair follicle generation by injecting adult human follicular epithelial and dermal papilla cells in nude mice
objective: objective: dermal papilla and hair epithelial stem cells regulate hair formation and growth cycle. damage to or losing of these cells can cause hair loss. although several studies have claimed to reconstitute hairs using rodent cells in animal model, a stable human hair follicle reconstitution protocol needs more studies. here in this study we evaluated hair induction through injecti...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2012
ISSN: 0022-202X
DOI: 10.1038/jid.2011.250